TB-500 is a research-use-only peptide derived from bovine pituitary extracts, primarily used in laboratory contexts for scientific investigations. It has been studied for its potential effects on tissue regeneration and cellular repair processes. For research use only.
Price range: $70.00 through $125.00
Every serious peptide company prominently displays this. Example Research Use Only All products offered by Dakota Peptology are intended strictly for laboratory research purposes.
Every serious peptide company prominently displays this. Example Research Use Only All products offered by TruPeptides are intended strictly for laboratory research purposes.
TB-500 is a synthetic peptide derived from bovine tissue and has been investigated for its potential role in research settings involving tissue regeneration, wound healing, and cellular repair processes. This peptide has garnered attention within scientific and academic communities for its structural and functional similarities to native proteins involved in extracellular matrix formation.
TB-500 has historically been explored in experimental animal models for its possible effects on tissue regeneration, particularly in scenarios where natural peptide signaling is either compromised or enhanced through synthetic intervention. Early studies indicated potential applications in models of muscle repair, skin regeneration, and even potential anti-aging effects under controlled research conditions.
The investigation of TB-500 primarily focuses on its ability to modulate cellular and extracellular matrix dynamics. It is structurally analogous to Thrombospondin-1, a protein known for its role in extracellular matrix organization and cell signaling. Research efforts have concentrated on its capacity to enhance tissue regeneration, improve wound healing responses, and potentially influence cellular proliferation and differentiation under in vitro and in vivo conditions.
It is important to note that TB-500 is not approved for therapeutic use in humans or animals and should only be utilized under the strict supervision of qualified researchers adhering to established scientific protocols.
For research use only. Not for human or animal consumption. This product is intended for academic or scientific investigation and should be handled with the appropriate safety precautions, including proper storage and disposal. Always consult with a qualified research specialist before conducting experiments involving TB-500.
Thymosin beta-4 (Tβ4), commonly known as TB-500, is a small actin-binding peptide present in nearly all mammalian cells.
Unlike traditional growth factors, Tβ4 operates intracellularly and rapidly mobilizes during injury, supporting early-stage repair, inflammation control, and tissue regeneration.
TB-500 exhibits multiple regenerative mechanisms including anti-inflammatory, antimicrobial, angiogenic, and anti-apoptotic effects.
It promotes cell migration, reduces tissue damage, supports vascular growth, and activates stem cells—creating a coordinated healing environment across tissues.
In corneal injury models, TB-500 accelerated epithelial healing, reduced inflammation, and preserved tissue clarity.
In dermal wounds, it enhanced wound closure, collagen formation, and angiogenesis—even in aged or diabetic models.
Additional observations included enhanced hair regrowth, indicating activation of follicular stem cells and regenerative pathways.
TB-500 demonstrated cardioprotective effects by reducing infarct size and improving heart function.
In neurological models, it preserved neuron survival and improved recovery after injury.
In sepsis models, it reduced mortality by suppressing inflammatory cytokines, highlighting systemic anti-inflammatory benefits.
TB-500 activates pathways such as integrin-linked kinase (ILK) and Akt, promoting cell survival, migration, and angiogenesis.
It also modulates nitric oxide signaling, reduces inflammation, and stimulates stem cell activation—enabling multi-system regeneration.
Across multiple species including rats, dogs, and monkeys, TB-500 demonstrated excellent safety even at high doses.
No toxic effects were observed, supporting its strong tolerability profile in preclinical studies.
TB-500 exhibited broad regenerative capabilities across multiple tissues, including skin, heart, and nervous system.
Its ability to simultaneously modulate inflammation, angiogenesis, and cellular repair positions it as a next-generation regenerative peptide in research settings.
